Vascular Cell Apoptosis
نویسندگان
چکیده
منابع مشابه
Applications of Cell Therapy in Vascular Surgery
Trying to use embryonic stem cells about 20 years ago, working with animals, especially rats began. During these years , many experiments in mouse embryonic stem cells to transform into a variety of cells and transplanting them were led to remarkable success . In the next issue of human stem cells were considered successful until finally in 1998 the first report was published in the proliferat...
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We hypothesized that the pathogenesis of diabetic vasculopathy involves the abnormal regulation of vascular smooth muscle cell (VSMC) apoptosis. In nondiabetic mice, a reduction in carotid artery blood flow resulted in a significant loss of medial VSMCs via apoptosis (normal flow 8461 viable VSMCs, reduced flow 7065 viable VSMCs; n512, P,0.01). In contrast, flow-induced VSMC apoptosis was marke...
متن کاملThe regulation of vascular smooth muscle cell apoptosis.
Apoptosis describes the morphological changes that identify a specific form of regulated cell death. Over recent years, the importance of either aberrant onset or suppression of apoptosis within tissues has become apparent and is associated with the development of several terminal diseases. Here we describe the relevance of apoptosis to the maintenance of vascular homeostasis. Specifically, we ...
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Elevated blood glucose in uncontrolled diabetes is causally correlated with diabetic microangiopathy. Hyperglycemia-triggered accelerated endothelial cell apoptosis is a critical event in the process of diabetes-associated microvascular disease. The conditionally semiessential amino acid taurine has been previously shown to protect against human endothelial cell apoptosis. Therefore, this study...
متن کاملReactive oxygen species induce apoptosis of vascular smooth muscle cell.
Apoptosis of vascular smooth muscle cell (VSMC) plays an important role in the genesis of atherosclerosis and restenosis. In order to investigate the role of reactive oxygen species in the induction of VSMC apoptosis, rat VSMCs were treated with glucose oxidase/glucose (GO/G) or diethylmaleate (DEM). The results showed that GO/G and DEM led to VSMC death. Administration of catalase, superoxide ...
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ژورنال
عنوان ژورنال: Circulation
سال: 1999
ISSN: 0009-7322,1524-4539
DOI: 10.1161/01.cir.99.15.2019